1
Faculty of Medical Sciences, Tarbiat Modares University
2
Faculty of Medical Sciences, Tarbiat Modares University.
3
Medical Sciences Faculty, Tarbiat Modares University
10.32598/ARI.81.3.3352
Abstract
Introduction: Despite recent advances in the treatment of cerebral toxoplasmosis, monitoring parasite load and treatment response is still challenging. In the present study, the effect of atovaquone (AT) and clindamycin (CL), alone and in combination, on chronic cerebral toxoplasmosis caused by the PRU strain of Toxoplasma gondii was investigated in BALB/c mice. Materials & Methods: BALB/c mice aged 6 to 8 weeks were infected by intraperitoneal inoculation of brain cysts of the PRU strain of T. gondii. Then, the mice were divided into five groups as follows: Group 1 included mice treated with 100 mg/kg of AT, group 2 included mice treated with 400 mg/kg per day of CL, group 3 included mice treated with the combination (AT+CL), group 4 included untreated, infected mice as a positive control (PC), and group 5 included untreated, uninfected mice as a negative control (NC). After the completion of the treatment period, the effect of the drugs in reducing or eliminating parasites in the brain was evaluated by counting the number of brain cysts. Results: The results showed that although AT and CL did not completely remove the cysts from the brain tissue of mice, they significantly reduced the number of tissue cysts in the brain tissue of the treated mice compared to the untreated control group (PC) (P<0.0001). AT had a greater anti-toxoplasmic effect than CL, and the difference between the two drugs was highly significant. Conclusion: In conclusion, considering the risks of infection with different strains of T. gondii, it is necessary to emphasize the importance of developing effective therapeutic interventions for toxoplasmosis.
Dalimi, A. , Zouei, N. and Pirestani, M. (2026). The Therapeutic Effects of Atovaquone and Clindamycin on the Reduction of Tissue Cysts of the PRU Strain of Toxoplasma gondii. Archives of Razi Institute, 81(3), 591-598. doi: 10.32598/ARI.81.3.3352
MLA
Dalimi, A. , , Zouei, N. , and Pirestani, M. . "The Therapeutic Effects of Atovaquone and Clindamycin on the Reduction of Tissue Cysts of the PRU Strain of Toxoplasma gondii", Archives of Razi Institute, 81, 3, 2026, 591-598. doi: 10.32598/ARI.81.3.3352
HARVARD
Dalimi, A., Zouei, N., Pirestani, M. (2026). 'The Therapeutic Effects of Atovaquone and Clindamycin on the Reduction of Tissue Cysts of the PRU Strain of Toxoplasma gondii', Archives of Razi Institute, 81(3), pp. 591-598. doi: 10.32598/ARI.81.3.3352
CHICAGO
A. Dalimi , N. Zouei and M. Pirestani, "The Therapeutic Effects of Atovaquone and Clindamycin on the Reduction of Tissue Cysts of the PRU Strain of Toxoplasma gondii," Archives of Razi Institute, 81 3 (2026): 591-598, doi: 10.32598/ARI.81.3.3352
VANCOUVER
Dalimi, A., Zouei, N., Pirestani, M. The Therapeutic Effects of Atovaquone and Clindamycin on the Reduction of Tissue Cysts of the PRU Strain of Toxoplasma gondii. Archives of Razi Institute, 2026; 81(3): 591-598. doi: 10.32598/ARI.81.3.3352
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