Correlation of c-reactive protein and serum iron levels with syntax score in coronary artery disease

Document Type: Original Articles

Author

Department of Cardiology Faculty of Medicine, Nigde Omer Halisdemir University, Campus, 51240, Nigde, Turkey

Abstract

Abstract:

Objectives: Cardiovascular diseases are one of the most common causes of morbidity and mortality in the world. There are lots of risk factors in cardiovascular disease. Atherosclerosis is an inflammatory process. Serum C-reactive protein (CRP), is an acute-phase protein rises in response to inflammation. Serum iron (Fe) is one of the essential metals to human body. Inflammation and infection are characterized by changes in Fe metabolism. Since atherosclerosis is an inflammatory process, changes in CRP and serum iron levels are expected. However, the distribution of the disease in the coronary arteries is important for mortality and morbidity. The distribution of the disease can be determined by syntax score.
Materials and methods: The study included 407 patients (56.4± 10.7years, 51.4% males). In the study 53 patients had critical lesions and 354 had no critical lesions. According to the baseline coronary angiograms, syntax score was calculated in all patients. The laboratory variables including hemoglobin levels, blood glucose, creatinine, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG), Fe, and CRP were studied.
Results: The study included 407 patients (56.4± 10.7years, 51.4% males). the study 53 patients had critical lesions and 354 had no critical lesions. laboratory parameters of all groups CRP levels mean 0.75±1.8mg/dl, Fe mean 80.4±27.5mg/dl and syntax score mean 1.5±4.8 were calculated. High syntax score levels correlated with Fe and CRP levels.
Conclusions: The findings of the present study showed elevated serum iron and CRP concentrations to be associated with increased syntax score and atherosclerosis severity.
Keywords: Atherosclerosis; C-reactive protein; serum iron; syntax score

Keywords