TY - JOUR ID - 121585 TI - Correlation of C-Reactive Protein and Serum Iron Levels with Syntax Score JO - Archives of Razi Institute JA - ARI LA - en SN - 0365-3439 AU - Ozdemir, B. AD - Department of Cardiology Faculty of Medicine, Nigde Omer Halisdemir University, Campus, 51240, Nigde, Turkey Y1 - 2020 PY - 2020 VL - 75 IS - 3 SP - 413 EP - 418 KW - atherosclerosis KW - C-reactive protein KW - serum iron KW - syntax score DO - 10.22092/ari.2020.128122.1404 N2 - Cardiovascular disease is one of the most common causes of morbidity and mortality in the world. Atherosclerosis is an inflammatory process, and serum C-reactive protein (CRP) is an acute-phase protein rising in response to inflammation. Serum iron (Fe) is one of the essential metals for the human body. Inflammation and infection are characterized by changes in Fe metabolism. Since atherosclerosis is an inflammatory process, changes in CRP and serum Fe levels are expected. However, the distribution of the disease in the coronary arteries is important for mortality and morbidity. The distribution of the disease can be determined by the syntax score. This study included 407 patients with a mean age of 56.4±10.7 years. The majority of the patients were male (51.4%). In this study, 53 and 354 patients had critical and no critical lesions, respectively. According to the baseline coronary angiograms, the syntax score was calculated in all patients. The laboratory variables, including hemoglobin levels, blood glucose, creatinine, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, Fe, and CRP were also evaluated in this study. Regarding the laboratory parameters of all groups, the mean CRP levels, Fe levels, and syntax score were estimated at 0.75±1.8 mg/dl, 80.4±27.5 mg/dl, and 1.5±4.8, respectively. Furthermore, a high syntax score correlated with Fe and CRP levels. Based on the findings of the present study, elevated serum Fe and CRP concentrations were associated with increased syntax score and atherosclerosis severity. UR - https://archrazi.areeo.ac.ir/article_121585.html L1 - https://archrazi.areeo.ac.ir/article_121585_732826f59c5b7129f9aa9ae4695d90ab.pdf ER -