Document Type : Original Articles
Authors
1
Department of clinical sciences, faculty of veterinary medicine, shahid chamran university of Ahvaz, IRAN
2
post-graguate student of Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
4
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
5
Department of Clinical sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
10.22092/ari.2025.368057.3475
Abstract
Disruption of the endometrial barrier after gestation leads to devastating effects on the cow's reproductive system. However, the accumulating immune responses help repair and defend the endometrium against microbial infections. Nevertheless, excessive inflammation could lead to chronic inflammation and consequently result in reproductive issues. The administration of NSAIDs can reduce the harmful effects of excessive inflammation, modulate the immune response, and improve reproductive indices in postpartum dairy cows. The aim of this study is to evaluate the side effects of NSAID administration on humoral immune responses, which could potentially inform the development of more effective treatment strategies for postpartum Hostein cows. The study involved a total of 60 apparently healthy cows, which were divided into three groups: flunixin meglumine, meloxicam, and control. The test groups were treated at 3 and 8 days after calving. To assess the humoral immune responses, the IgG and IgM titers against Escherichia coli and Trueperella pyogenes, were determined on Day 4,9 and 15 after gestations. The results of the study showed that the drugs did not significantly affect the total specific and nonspecific antibody levels against tested pathogens. A time-dependent decrease and increase in the levels of IgM and IgG antibodies against E. coli and T. pyogenes were observed in all groups. The results showed a reduction in IgM and IgG titers against both pathogens after treatment with meloxicam and flunixin respectively. However, the elevation of IgG and IgM titers indicated that the treatment affected antibody isotype switching rather than suppressing the humoral immune responses.
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