Biological Activities of Caffeic Acid Phenethyl Ester: Comparative Analysis of Natural Products and Synthetic Derivatives

Selamoglu, Zeliha; Naeem, Muhammad Yasir

doi:10.22092/ari.2024.366561.3268

Biological Activities of Caffeic Acid Phenethyl Ester: Comparative Analysis of Natural Products and Synthetic Derivatives

Articles in Press

Document Type : Review Article

Authors

¹ Nigde Omer Halisdemir University

² Department of Plant Production and Technologies. Faculty of Agricultural Sciences and Technologies. Nigde Omer Halisdemir University Nigde, Türkiye

10.22092/ari.2024.366561.3268

Abstract

Caffeic acid phenethyl ester (CAPE) is a phenolic compound naturally found in propolis and various plant extracts, presenting itself as a promising candidate for plant-based pharmaceuticals due to its diverse biological effects. It boasts significant antioxidant, antimicrobial, anti-inflammatory, and anticancer properties, making it a subject of intense research for potential therapeutic applications. Caffeic Acid Phenethyl Ester (CAPE) derivatives are significant compounds that exhibit a range of biological activities due to the precise modification of their chemical structures. Derived from the natural form of CAPE, these derivatives have been developed to offer more effective and targeted therapies for various diseases. Natural CAPE exhibits distinct advantages over synthetic analogues, including better bioavailability, enhanced biological activity, and a generally safer profile. In contrast, synthetic CAPE derivatives are strategically designed to improve bioavailability and target specific biological pathways, albeit often with varying degrees of effectiveness and safety compared to their natural counterparts. Caffeic Acid Phenethyl Ester (CAPE), derived from natural sources, exhibits diverse biological activities including antioxidant, antimicrobial, anti-inflammatory, and anticancer properties, making it a valuable compound in healthcare applications. Natural CAPE is favored over synthetic derivatives due to its broader spectrum of biological effects and lower incidence of adverse effects, enhancing its attractiveness for pharmaceutical and therapeutic uses. These multifaceted biological activities underscore CAPE's importance in healthcare, whether derived naturally or synthetically. This review aims to compare the bioavailability profiles of natural and synthetic CAPE, highlighting their respective biological potentials. By providing a comprehensive overview, it aims to guide neuroscientists and pharmaceutical researchers in leveraging both forms effectively for therapeutic innovations. This exploration may pave the way for future advancements in utilizing CAPE and its derivatives in clinical settings.

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