Document Type : Original Articles
Authors
1
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2
Division of PhysiologyDepartment of Basic Sciences Faculty of Veterinary Medicine Science and Research Branch Islamic Azad University-Tehran-Iran
3
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran
10.22092/ari.2024.367427.3390
Abstract
This paper aimed to determine effects of exposure to sericin on serum GH, IGF-1 and antioxidant levels following parturition in mice. Forty pregnant female NMRI mice were allocated into four groups. In the control group, pregnant mice were given water as a placebo, whereas pregnant female mice in groups 2-4 were orally administered sericin (112.5, 225, and 450 mg/kg) at different days of gestation (5, 8, 11, 14, and 17). Following postpartum, open field test (OFT), forced swimming test ( FST ), tail suspension test ( TST ) and open field tests were used to evaluate depressive-like antidepressant activity of sericin. At the end of the study, serum growth hormone (GH), Insulin-like growth factor-1 (IGF-1), Malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant status (TAS) levels were determined. According to the results, sericin administration during pregnancy decreased immobility time in FST and TST and increased number of cross in OFT compared to control group (P<0.05). Exposure to sericin significantly decreased serum MDA while increased SOD, GPx and TAS levels compared with the control group (P<0.05). Also, sericin exposure during gestation significantly increased serum GH and IGF-1 levels compared to the control group (P<0.05). These results suggested pre-partum administration of sericin has antidepressant effect in postpartum mice.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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