Evaluation of Inflammatory Markers (PV, ESR, CRP) in the Early Diagnosis of Cancer and Their Relationship With Survival Rate

Salehi Kahyesh, Roya; Halakou, Ahmad; Farhadi Kia, Arta; Perk, Emir Yiğit; Ahani, Mahshid; Bitaraf, Saeid

doi:10.32598/ARI.80.5.3136

Evaluation of Inflammatory Markers (PV, ESR, CRP) in the Early Diagnosis of Cancer and Their Relationship With Survival Rate

Document Type : Original Articles

Authors

¹ Thalassemia & Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

² Department of Biology, IZ.C., Islamic Azad University, Izeh, Iran.

³ Faculty of Medical Science, Izmir Ekonomi University, Izmir, Turkey.

10.32598/ARI.80.5.3136

Abstract

Introduction: This study investigates the prevalence of cancer, compares inflammatory factors, and examines how inflammatory markers— C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and plasma viscosity (PV)—can aid in the early diagnosis of cancer in primary care settings.
Materials & Methods: We included newly diagnosed patients of all types of malignancy (children and adults) in this retrospective study from 2018 to 2023. The results of CRP, ESR, PV tests, and demographic data (age, gender, type of malignancy, and survival) were collected. Research data were analyzed using the t-test and chi-square statistical methods. According to the results, the average ESR and PV were higher in patients who died than in those who survived (P<0.05). In addition, it was shown that there was a significant relationship between the age and gender of the patients and their survival (P<0.05). It was also shown that there was a significant relationship between the survival of patients with ESR, CRP, and PV across different cancers (P<0.05). On the other hand, a significant correlation was found between ESR, CRP, and PV among different cancers (P<0.05).
Results: Based on the results, it was shown that the average ESR and PV were higher in patients who died than in those who survived (P<0.05). In addition, it was shown that there was a significant relationship between the age and gender of the patients and their survival (P<0.05). It was also shown that there was a significant relationship between the survival of patients and ESR, CRP and PV across different cancers (P<0.05). On the other hand, it was shown that there was a significant correlation between ESR, CRP and PV among different cancers (P<0.05).
Conclusion: To halt the progression of acute inflammation to chronic inflammation and mitigate its harmful implications, it is essential to reduce the inflammatory response. Efficient management of inflammation is crucial in preventing patient mortality and is thus essential for the treatment and survival of patients with malignancies.

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