Investigating the effect of eradication of Helicobacter pylori infection in controlling blood sugar in diabetic patients

Document Type : Original Articles

Author

Forensic Evidences Dept, Alsalam University College, Baghdad, Iraq

10.32592/ARI.2024.79.6.1235

Abstract

Helicobacter pylori is one of the most common chronic infections in the world. It is believed that diabetes mellitus increases the incidence of Helicobacter pylori infection, but the related data on the relationship between Helicobacter pylori and the level of blood sugar control (HbA1C) in diabetics are few and contradictory. Therefore, the prese nt study aims to investigate the rooting effect of Helicobacter pylori infection in blood sugar control of diabetic patients was done. In this experimental study, (after-before) 61 type II diabetic patients with or without dyspepsia symptoms in whom Helicobacter pylori infection was proven by anti-Helicobacter pylori IgG serological method; under the treatment of four anti-Helicobacter pylori drug regimen (bismuth + metronidazole) + tetracycline + omeprazole). The amount of HbAlC was measured before starting the treatment of Helicobacter pylori infection and 2 months after the treatment of the infection, after proving the eradication of Helicobacter pylori infection with Urea Breath Test and the average values of HbAlC before and after the treatment of Helicobacter pylori infection. It was compared using SPSS software and Paired Test-T statistical test. Results indicated that average age of the studied subjects was 52.4 ± 10.4 years, and the number of male patients was 39 (63.9 percent) and the number of female patients was 22 (36.1 percent). The average duration of diabetes at the time of diagnosis in the study subjects was 8.7 ±5.5 years. In this study, Helicobacter pylori infection was eradicated in all the studied patients, which was proved by the urea breath test (UBT). The average HbAlC level before treatment was 8.6 ± 1.2, and this value after treatment was 7.9 ± 1.2, this change is statistically significant (P<0.05). It was Concluded that a positive relationship between the eradication effect of Helicobacter pylori and blood sugar control (reduction of HbAlC) was found; however, more studies in diabetic patients are recommended to obtain more accurate results.

Keywords

Main Subjects

References

  1. Faucil; Braunwald; Kasper; Hauser; longo; jameson; loscalzo; pepticulcer Disease and Related Disorders. john Del Valle, Harrison's principles of Internal Medicine, 17th Edition Mc Graw Hill. Medical publishing Division. 2008 pp 1858- 1860.
  2. C, cavallo perin; etc. Helicobacter pylori infection and diabetic complications DiabNutr. Metab. 2004;17:65.
  3. Gulcelik NE, Kaya E. etc. Helicobacter pylori prevalence in diabetic patients and its relationship with Dyspepsia and autonomic neuropathy. J. Endocrin Unvest. 2005;28(3):214-7.
  4. Samahelova A. et al. clinical importance of Helicobacter pylori infection in patients with diabetes Mellitus. Vinitr Lex. 2004;5(5):350-3.
  5. Kyriazanos ID. Sriniadakis I. Rtc. Impact of bodymass index on fasting blood glucose concentration among Helicobacter pylori carriers. Dif Dis. 2003;21(3):262-5.
  6. T. Dorchy H. et al. Helicobacter pylori Infection and eradication are not Related to glycosylated. Hemoglobin level (HbA1C) in young patients with type 1 Diabets. Press Med. 2007.
  7. Gino G. Fetnandini- Paredes, et al. In patiets with Type 2 Diabetes Mellitus, Are glycosylated hemoglobin levels higher for those with Helicobacter pylori infection than those without infection? Faculty of peru. 2006;11:103-8.
  8. Mehrabian AA. Sedigh Tonekaboni B, et al. Study of Helicobacter pylori infection in 76 people with insulin independent diabetes mellitus In patients in Shohada hospital in 2001-2002. Medical Thesis. 2002-2003.
  9. Shams B, Hashemipour M, Saadat SH. Etc. Prevalence of Helicobacter infection in Type 1 diabetic children referring to Isfahan endocrine & metabolism research center. IRAN Journal of diabetes and lipid disorders. 2003;1(3):40-35.
  10. Bener A, Micallerr, Afirin, etc. Association between Type 2 diabetes mellitus and Helicobacter pylori infeection. Turkj Gastrointestinal. 2007;18(4):225-9.
  11. Sherifa Ahmed, NaBila F. Amine. Etc. Vascular risks and complications in diabetes mellitus, the role of Helicobacter pylori infection. Journal of stroke and vascular disease. 2008;17(2):86-94.
  12. Hanefeld M. schaper F, kochierc. Effect of acarbose on vascular Disease in patients with abnormal glucose Tolerance. Cardioras Drugs ther. 2008;22(3):225-31.
  13. Niemela S.Kartunnen T, Korhonen T, et al. Could Helicobacter pylori infection increase therisk of ischemic heart disease by modifying serum lipid concentrations, Heart. 1996;75:573-572.
  14. De luisd A, Gatcia Areallo A, lasuncino et al. Improvement in lipid and haemostasis patterns after Helicobacter pylori infection eradication in type 1 diabetic patients. 1999;4:227- 231.
  15. Simon OA, Görbe A, Hegyi P, Szakó L, Oštarijaš E, Dembrovszky F, et al. Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta-Analysis. Journal of the American Heart Association. 2022;11(3):e022919.
  16. Nam SJ, Park SC, Lee SH, Choi DW, Lee SJ, Bang CS, et al. Helicobacter pylori eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study. SAGE Open Medicine. 2019;7:2050312119832093.
  17. Vafaeimanesh J, Rajabzadeh R, Ahmadi A, Moshtaghi M, Banikarim S, Hajiebrahimi S, et al. Effect of Helicobacter pylori eradication on glycaemia control in patients with type 2 diabetes mellitus and comparison of two therapeutic regimens. Arab Journal of Gastroenterology. 2013;14(2):55-8.
  18. Cheng KP, Yang YJ, Hung HC, Lin CH, Wu CT, Hung MH, et al. Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection. Journal of Diabetes Investigation. 2019;10(4):1092-101.
Archives of Razi Institute
Volume 79, Issue 6
November and December 2024
Pages 1235-1239

Files

Share

How to cite

Statistics