Estimation of Salivary Levels of an Inhibitory Apoptotic Protein Survivin in Oral leukoplakia and Squamous cell carcinoma

Document Type : Original Articles

Authors

1 University of Glasgow, Glasgow Dental School & Hospital, 378, Sauchiehall St, Glasgow

2 Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences and Hospital, Constituent Unit of KLE Academy of Higher Education and Research, Belgaum -590010. Karnataka - INDIA.

10.22092/ari.2024.364335.2965

Abstract

Carcinogenesis is set due to excessive proliferation of tumor cells and decrease in rate of apoptosis. Several molecules play a key role in this process, one such molecule that is known to control this process is Survivin. Expression of Survivin is detected in embryonic and adult tissues with demand of high rate of turnover and also in tissue sections of oral precancer and cancer. But data regarding detection of Survivin in saliva is limited. Thus our objective is to estimate and compare salivary Survivin levels (SSL) in normal oral mucosa (NOM), oral Leukoplakia (OL) and Squamous cell carcinoma (OSCC) to demonstrate it as a predictive biomarker. Whole Saliva samples were collected from all subjects and assessed for Salivary Survivin levels using ELISA technique. Kruskall Wallis test was applied to compare SSL We found that mean SSL in control group was 301.9 ± 180.35 ng/dl and study groups of OL and OSCC was 285 ± 140.4 and 316.5 ± 176.72 ng/dl. In OL group, highest value was noted in severe dysplasia (407.4 ng/dl) and in OSCC group highest value was noted in WDSCC (311.5ng/dl). Due to inconsistency in distribution of sample, our findings were found to be non-significant (p = 0.796). Our study is first of its kind to detect SSL in NOM, we propose that Survivin do have definitive role in maintaining normal homeostasis of oral mucosa. Gradual upregulation and downregulation of SSL in OL and OSCC can predict aggressive nature of malignancy. Hence, Survivin detection in saliva can be used as a predictive marker of disease progression of oral precancer and cancer.

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Archives of Razi Institute

Articles in Press, Accepted Manuscript
Available Online from 17 April 2024

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