Riboceine Regimen Circumvents Reserpine-Induced Hepatotoxicity via the Modulation of Key Liver Function Markers in Adult Male Wistar Rats

Document Type : Original Articles

Authors

1 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Osun State, Nigeria.

2 Department of Anatomy, University of Medical Sciences, Ondo City, Nigeria

3 Anatomy Unit, Department of Medical Laboratory Sciences, College of Basic and Health Sciences, Fountain University, Osogbo, Osun State, Nigeria.

4 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Kwara State, Nigeria.

10.32592/ARI.2025.80.2.508

Abstract

Reserpine, an antipsychotic and antihypertensive medication, has been associated with liver damage and dysfunction. This study examined the potential hepatoprotective effect of a riboceine regimen against reserpine-induced hepatotoxicity in adult male Wistar rats. Twenty-five (25) Adult male Wistar rats were randomly divided into five groups: Control, Reserpine, Reserpine + Citalopram, Reserpine + Riboceine, and Reserpine + Citalopram + Riboceine. Liver function markers, including alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP), were analyzed in serum samples to assess liver health. Additionally, a histopathological examination of liver tissue was performed to visualize any morphological changes.
Rats treated with reserpine alone displayed a significant increase in serum ALT and AST, levels compared to the control group, indicating hepatocellular damage. In contrast, the Riboceine + Reserpine group exhibited a marked reduction in ALT and AST levels compared to the Reserpine group, suggesting a protective effect of riboceine against reserpine-induced hepatotoxicity. No significant difference was observed in the serum level of ALP across the experimental groups. Histopathological examination confirmed the attenuated liver injury in the Riboceine + Reserpine group, with a reduction in necrotic areas and inflammation compared to the Reserpine group.
The results demonstrate that a riboceine regimen effectively circumvents reserpine-induced hepatotoxicity in adult male Wistar rats. The modulation of key liver function markers, along with histopathological evidence, supports the hepatoprotective role of riboceine in mitigating liver damage induced by reserpine. This study provides promising insights into the potential therapeutic application of riboceine as a hepatoprotective agent, which could be beneficial for patients undergoing treatment with reserpine or similar medications. Further research is warranted to explore the underlying mechanisms of riboceine's protective effects and its potential clinical applications

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Archives of Razi Institute
Volume 80, Issue 2
March and April 2025
Pages 508-515

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