Novel drug delivery systems for combating H. pylori: A brief review

Document Type : Review Article

Authors

1 Department of Pharmaceutics, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 1Department of Pharmaceutics, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran

10.32592/ARI.2024.79.5.903

Abstract

Helicobacter pylori infection stands out as a primary cause of gastritis, with the alarming potential to progress into gastric cancer if left unaddressed. However, the efficacy of conventional treatments is undermined by the escalating challenge of antibiotic resistance and the necessity for complex multi-drug and high-dose therapeutic regimens. Complicating matters further, factors like biofilm formation, efflux pumps, and gene mutations significantly heighten the risk of treatment failure. In light of these formidable obstacles, contemporary drug delivery systems emerge as crucial allies in the battle against H. pylori. These advanced systems offer key advantages, such as enhanced drug protection, controlled release, and targeted delivery to specific tissues. Nanoparticles, in particular, hold promise in combating H. pylori infection through diverse mechanisms, ranging from direct drug delivery into the bacteria to the destruction of bacterial walls and the generation of free radicals. This review navigates through the current therapeutic landscape, shedding light on both existing and evolving treatment options. It delves into the transformative potential of novel drug delivery systems, including micro- and nanoparticles, as instrumental players in the intricate realm of H. pylori infection treatment. By exploring the intricate interplay between infection dynamics and cutting-edge delivery technologies, this review aims to carve a path towards more effective and tailored interventions against this persistent threat. As we learn more about H. pylori infection, new treatments and better ways to deliver drugs offer hope for a more effective and personalized approach to fighting this persistent health problem. This dynamic intersection of microbiology and nanotechnology exemplifies the relentless pursuit of innovative solutions to safeguard against the formidable challenges posed by H. pylori, ultimately offering hope for improved patient outcomes and a healthier future.

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Archives of Razi Institute
Volume 79, Issue 5
September and October 2024
Pages 903-914

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