Smoking destroys the vascular system, increases plaque deposits in atherosclerosis, and increases inflammation. The present study was performed to determine the effect of smoking on the levels of low-density lipoprotein and very low-density lipoprotein in smokers. A cross-control study was carried out in the outpatient clinic in Baghdad, Iraq. The study was carried out 60 by individuals from February 2021 to July 2021. Participants in this study included adult smokers and non-smokers of both genders, and the levels of LDL and VLDL were determined using an Automatic Chemistry Analyze. The results revealed that the total number of smokers was 60 individuals from both genders; there was a significant difference in mean low-density lipoprotein and very low-density lipoprotein levels. There is a significant difference in LDL Values between non-smokers and smokers (129.853±7.880; P<0.05). Non-smokers showed lower LDL values (104.460±7.950; P<0.05). Regarding VLDL values, results revealed that smokers were showing higher values than a non-smoker (49.641±4.02), (28.986±1.676) respectively, P<0.05). LDL and VLDL levels are more prevalent in current cigarette smokers than in non-smokers. Heavy smokers have higher LDL and VLDL values for a cigarette than non-smokers, which is consistent with observations in other populations.
Yusuf S, Hawken S, Ôunpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937-52.
Śliwińska-Mossoń M, Mihułka E, Milnerowicz H. Assessment of lipid profile in non-smoking and smoking young health persons. Prz Lek. 2014;71(11):585-7.
Rao Ch S, Subash YE. The effect of chronic tobacco smoking and chewing on the lipid profile. J Clin Diagn Res. 2013;7(1):31-4.
Selya AS, Hesse ND. Time to first cigarette and serum cholesterol levels. Soc Sci Med. 2017;174:213-9.
Hevonoja T, Pentikäinen MO, Hyvönen MT, Kovanen PT, Ala-Korpela M. Structure of low density lipoprotein (LDL) particles: Basis for understanding molecular changes in modified LDL. Biochim Biophys Acta Mol Cell Biol Lipids. 2000;1488(3):189-210.
Heidemann BE, Koopal C, Bots ML, Asselbergs FW, Westerink J, Visseren FLJ. The relation between VLDL-cholesterol and risk of cardiovascular events in patients with manifest cardiovascular disease. Int J Cardiol. 2021;322:251-7.
Meenakshisundaram R, Rajendiran C, Thirumalaikolundusubramanian P. Lipid and lipoprotein profiles among middle aged male smokers: a study from southern India. Tob Induc Dis. 2010;8:11.
Venkatesan A, Hemalatha A, Bobby Z, Selvaraj N, Sathiyapriya V. Effect of smoking on lipid profile and lipid peroxidation in normal subjects. Indian journal of physiology and pharmacology. 2006;50(3):273-8.
Chelland Campbell S, Moffatt RJ, Stamford BA. Smoking and smoking cessation -- the relationship between cardiovascular disease and lipoprotein metabolism: a review. Atherosclerosis. 2008;201(2):225-35.
Gepner AD, Piper ME, Johnson HM, Fiore MC, Baker TB, Stein JH. Effects of smoking and smoking cessation on lipids and lipoproteins: outcomes from a randomized clinical trial. Am Heart J. 2011;161(1):145-51.
Hallit S, Zoghbi M, Hallit R, Youssef L, Costantine R, Kheir N, et al. Effect of exclusive cigarette smoking and in combination with waterpipe smoking on lipoproteins. J Epidemiol Glob Health. 2017;7(4):269-75.
Krupski WC. The peripheral vascular consequences of smoking. Ann Vasc Surg. 1991;5(3):291-304.
Jain RB, Ducatman A. Associations between smoking and lipid/lipoprotein concentrations among US adults aged >/=20 years. J Circ Biomark. 2018;7:1849454418779310.
Gossett LK, Johnson HM, Piper ME, Fiore MC, Baker TB, Stein JH. Smoking intensity and lipoprotein abnormalities in active smokers. J Clin Lipidol. 2009;3(6):372-8.
Freeman DJ, Griffin BA, Murray E, Lindsay GM, Gaffney D, Packard CJ, et al. Smoking and plasma lipoproteins in man: effects on low density lipoprotein cholesterol levels and high density lipoprotein subfraction distribution. Eur J Clin Invest. 1993;23(10):630-40.
Hussein Ali, E., Hussein Abod Al-Khafaji, K., & Hassan Abood, A. (2022). Effect of Smoking on Low-Density Lipoproteins Level in Human. Archives of Razi Institute, 77(5), 1971-1974. doi: 10.22092/ari.2022.358326.2191
MLA
E Hussein Ali; K Hussein Abod Al-Khafaji; A Hassan Abood. "Effect of Smoking on Low-Density Lipoproteins Level in Human". Archives of Razi Institute, 77, 5, 2022, 1971-1974. doi: 10.22092/ari.2022.358326.2191
HARVARD
Hussein Ali, E., Hussein Abod Al-Khafaji, K., Hassan Abood, A. (2022). 'Effect of Smoking on Low-Density Lipoproteins Level in Human', Archives of Razi Institute, 77(5), pp. 1971-1974. doi: 10.22092/ari.2022.358326.2191
VANCOUVER
Hussein Ali, E., Hussein Abod Al-Khafaji, K., Hassan Abood, A. Effect of Smoking on Low-Density Lipoproteins Level in Human. Archives of Razi Institute, 2022; 77(5): 1971-1974. doi: 10.22092/ari.2022.358326.2191