Contractile Responses of Murine Hearts Subjected to Different Modes of Motor Activity to Traumatic Brain Injury

Document Type : Original Articles

Authors

1 Traumatologist-orthopedist GAUZ "RKB", Ministry of Health of the Republic of Tatarstan, Kazan Federal University, Kazan, Russia

2 Department of Biomedical Engineering and Innovation Management, Kazan Federal University , Kazan, Russia, ORCID - 0000-0002-5279-2623

3 Institute of Fundamental Medicine and Biology, Head of the Department of Human Health Protection, Kazan Federal University, Kazan, Russia, ORCID - http://orcid.org/0000-0001-9557-1639

4 Engineering Institute, Department of Biomedical Engineering and Innovation Management, Kazan Federal University, Kazan, Russia, ORCID - http://orcid.org/0000-0001-9281-2791

5 Institute of Fundamental Medicine and Biology, Department of Human Health Protection, Kazan Federal University, Kazan, Russia, ORCID 0000-0003-0649-5393

Abstract

For the first time ever, this research studied the response of stroke volume in animals to various modes of motor activity after a traumatic brain injury. The study showed a pronounced decrease in stroke volume (SV) the first day after modeling an open craniocerebral injury in rats of all age groups. At the same time, the smallest SV response to brain injury was observed in immature animals. After modeling a traumatic brain injury, it was found that the implementation of systematic dynamic exercises by animals of pre-senile agedoes not contribute to increase SV; a significant increase in SV after a traumatic brain injury is observed only in immature animals. It was revealed that limiting physical activity and the performance of isometric exercises after a traumatic brain injury restrain a natural increase in SV in immature rat pups and decrease SV in sexually mature and pre-senile animals.

Keywords

Main Subjects

Article Title [French]

Réponses Contractiles des Cœurs Murins Soumis à Différents Modes d'Activité Motrice à une Lésion Cérébrale Traumatique

Abstract [French]

Pour la toute première fois, cette recherche a étudié la réponse du volume systolique chez les animaux à divers modes d'activité motrice après une lésion cérébrale traumatique. L'étude a montré une diminution prononcée du volume systolique (VS) le premier jour après la modélisation d'une lésion cranio-cérébrale ouverte chez les rats de tous les groupes d'âge. Dans le même temps, la plus petite réponse SV aux lésions cérébrales a été observée chez les animaux immatures. Après avoir modélisé une lésion cérébrale traumatique, il s'est avéré que la mise en œuvre d'exercices dynamiques systématiques par des animaux d'âge présénile ne contribue pas à l'augmentation du VS; une augmentation significative du VS après une lésion cérébrale traumatique n'est observée que chez les animaux immatures. Il a été révélé que la limitation de l'activité physique et la performance des exercices isométriques après une lésion cérébrale traumatique restreignent une augmentation naturelle du VS chez les jeunes rats immatures et diminuent le VS chez les animaux sexuellement matures et préséniles

Keywords [French]

  • Lésion Cérébrale Traumatique
  • Volume Systolique
  • Modes D'activité Motrice

References

  1. Ovsiannikov DM, Chekhonatskii AA, Kolesov VN, AI. B. Social and epidemiological aspects of traumatic brain injury (review). J Med Sci Res. 2012;8(3):777-85.
  2. Raginov IS, Egorov VI, Valiullin LR, Vindzorova M, IN. C. Changes in the expression of different types of p2 receptors in epithelial and nervous tissues during posttraumatic regeneration in rats. Genes Cells. 2017;12(3):203.
  3. Raginov IS, Iasieva MR, MA. M. The effect of p2y and p2x receptor blockers on the cognitive functions in mice. Morphol. 2014;145(3):234.
  4. RR. N. The pumping function of the heart of the developing organism and its regulation in muscle training. Diss MD Biol. 1999;8(1):455.
  5. Sitdikov FG, Anikina TA, Gil'mutdinova RI. Adrenergic and cholinergic control on the heart in rat ontogenesis. Bull Exp Biol Med. 1998;126(3):925-7.
  6. Zefirov T. Nervous regulation of the heart rate in rats in postnatal ontogenesis: Author. diss. MD-Kazan; 1999.
  7. Zefirov TL, Chershintseva NN, Bilalova GA, Sitdikov FG, Dikopolskaia NB, MV. S. Adrenergic receptors in dopaminergic regulation of myocardial contractility in growing rats. Receptor intracellular signaling. 2019;7(2):194-7.
  8. TL. Z, NV. S. The effect of stimulation of the vagus nerve on the heart rate of rats with Obsidan-blocked β-adrenoceptor. Bull Exp Biol Med. 1998;12(1):612-4.
  9. TL. Z, RK. B, AM. K, II. K, NI. Z. The effect of experimental myocardial ischemia on the postoperative state of rats. Physiol Pathology blood circulation VII All-Russian School Conference Int participation. 2020;5(1):22.
  10. Kubicek WG, Kamegis JW, Patterson RP, Witsoe DA, RH. M. Development and evaluation of an impedance cardiac output system. Aerosp Med. 1966;37:8-12.
  11. Li M, West JW, Lai Y, Scheuer T, Catterall WA. Functional modulation of brain sodium channels by cAMP-dependent phosphorylation. Neuron. 1992;8(6):1151-9.
  12. Guyenet PG. Baroreceptor-mediated inhibition of A5 noradrenergic neurons. Brain Res. 1984;303(1):31-40.
Archives of Razi Institute
Volume 76, Issue 3
September 2021
Pages 631-638

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