Pretreatment with Ultrasonication Reduces the Size of Azelaic Acid-Chitosan Nanoparticles Prepared by Electrospray

Document Type : Original Articles

Authors

1 Nanobiotechology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Nowadays, electrospray is becoming a favourable approach for preparing monodispersed nanoparticles. However, this approach is quite recent and requires further works to optimize control over physicochemical properties of its products. This study aimed to determine the possible effects of sonication as a pretreatment to reduce the size of azelaic acid-chitosan particle before using electrospray. The results showed that sonication treatment can produce submicron particles of azelaic acid-chitosan. By diluting the solution and increasing sonication time and amplitude, smaller particles were obtained with the smallest one at 516 nm, sized by dynamic light scattering. The pretreated solution was then electrosprayed to reduce the size of nanoparticles to 80 nm, indicating that sonication may play an important role in reducing the size of electrosprayed nanoparticles. The electrosprayed nanoparticles were nearly monodispersed and almost spherical in shape.

Keywords

Main Subjects

Article Title [French]

Le prétraitement par ultrasonication réduit la taille des nanoparticules d'acide azélaïque-chitosane préparées par électrospray

Abstract [French]

L’electrospray est aujourd’hui une approche favorable pour la préparation de nanoparticules monodispersées. Cette méthodeest cependant assez récente et nécessite des travaux supplementaires afin demieux contrôler les propriétés physicochimiques des produits traités. Cette étude visait à déterminer les influences possibles d’un prétraitement par sonication sur la taille des particules issues d’une solution de chitosane-acide azélaïque. Les résultats ont montré que le traitement par ultrasons permet de produire des particules submicroniques d'acide azélaïque-chitosane. En diluant la solution et en augmentant le temps et l'amplitude de la sonication, des particules plus petites sontobtenues dont lesplus petites ont été mesurées par diffusion dynamique de la lumière à 516 nm. La solution prétraitée a ensuite été soumise à uneélectropulvérisation afin de diminuer la taille des nanoparticules jusqu'à 80 nm. Ceci montre que la sonication peut jouer un rôle important dans la réduction de la taille des nanoparticules traitées par électrospray. Les nanoparticules issues de l’électrospray étaient plus ou moins monodispersées et de forme sphérique.

Keywords [French]

  • Electrospray
  • le chitosane
  • l'acide azélaïque
  • ultrasonication

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Archives of Razi Institute
Volume 73, Issue 1
March 2018
Pages 53-59

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