Interaction of Central Glutamatergic and Histaminergic Systems on Food Intake Regulation in Layer Chickens

Document Type : Original Articles

Authors

1 Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran

3 Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

Abstract

This study purposed to discover the connection between the central glutamatergic and histaminergic systems on feeding behavior in layer chickens. In the first experiment, chicks obtained intracerebroventricular (ICV) injections of saline (control solution), α-FMH (250 nmol), glutamate (300 nmol), and α-FMH + glutamate. Experiments 2-6 were comparable to the first experiment, apart from the birds being injected with chlorpheniramine (histamine H1 receptor antagonist, 300 nmol), famotidine (histamine H2 receptor antagonist, 82 nmol), and thioperamide (histamine H3 receptor antagonist, 300 nmol) instead of α-FMH. In Experiment five, experimental groups were divided into (A) control solution, (B) MK-801 (N-methyl-D-aspartate receptor antagonist, 15 nmol), (C) histamine (300 nmol) and (D) MK-801 + histamine. Experiments 6-10 and Experiment five were similar apart from the ICV injections of CNQX (AMPA receptor antagonist, 360 nm), UBP-302 (Kainate receptor antagonist, 390 nm), AIDA (mGluR1 antagonist, 2 nmol), LY341495 (mGluR2 antagonist, 150 nmol), and UBP1112 (mGluR3 antagonist, 2 nmol) given instead of MK-801. Afterward, cumulative food intake was recorded at30, 60, and 120 minutes after the injection process. According to the results, ICV injection of glutamate considerably reduced food intake (p<0.05). Co-injection of α-FMH + glutamate and/or chlorpheniramine + glutamate reduced the hypophagic influence of glutamate (p<0.05), whereas thioperamide + glutamate augmented glutamate-induced hypophagia in neonatal chicks (p<0.05). Co-injection of MK-801 + histamine or UBP-302 + histamine reduced the hypophagic influence of the histamine (p<0.05), whereas LY341495 + histamine augmented the hypophagic influence of the histamine (p<0.05). Given the results, it is suggested that the effect of the connection between these systems on the process of food intake regulation is mediated by H1 and H3 histamines as well as NMDA, Kainate, and mGluR2 glutamate receptors in neonatal layer chickens.

Keywords

Main Subjects

Article Title [French]

Interaction des Systèmes Glutamatergique et Histaminergique Centraux sur la Régulation de la Prise Alimentaire Chez les Poules Pondeuses

Abstract [French]

Cette étude visait à découvrir le lien entre les systèmes glutamatergique et histaminergique centraux sur le comportement alimentaire des poules pondeuses. Dans la première expérience, les poussins ont reçu des injections intracérébroventriculaires (ICV) de solution saline (solution de contrôle), de α-FMH (250 nmol), de glutamate (300 nmol) et de α-FMH + glutamate. Les expériences 2 à 6 étaient comparables à la première expérience, à l'exception des oiseaux ayant reçu une injection de chlorphéniramine (antagoniste du récepteur de l'histamine H1, 300 nmol), de la famotidine (antagoniste du récepteur de l'histamine H2, 82 nmol) et du thiopéramide (antagoniste du récepteur de l'histamine H3, 300 nmol) au lieu de α-FMH. Dans l'expérience cinq, les groupes expérimentaux ont été divisés en (A) solution de contrôle, (B) MK-801 (antagoniste du récepteur N-méthyl-D-aspartate, 15 nmol), (C) histamine (300 nmol) et (D) MK- 801 + histamine. Les expériences 6-10 et l'expérience cinq étaient similaires à l'exception des injections ICV de CNQX (antagoniste du récepteur AMPA, 360 nm), UBP-302 (antagoniste du récepteur Kainate, 390 nm), AIDA (antagoniste mGluR1, 2 nmol), LY341495 (antagoniste mGluR2, 150 nmol), et UBP1112 (antagoniste mGluR3, 2 nmol) administré à la place du MK-801. Par la suite, la prise alimentaire cumulative a été enregistrée à 30, 60 et 120 minutes après le processus d'injection. Selon les résultats, l'injection ICV de glutamate a considérablement réduit la prise alimentaire (p<0.05). La co-injection de α-FMH + glutamate et/ou chlorphéniramine + glutamate a réduit l'influence hypophagique du glutamate (p<0.05), tandis que le thiopéramide + glutamate a augmenté l'hypophagie induite par le glutamate chez les poussins nouveau-nés (p<0.05). La co-injection de MK-801 + histamine ou UBP-302 + histamine a réduit l'influence hypophagique de l'histamine (p<0.05), tandis que LY341495 + histamine a augmenté l'influence hypophagique de l'histamine (p<0.05). Compte tenu des résultats, il est suggéré que l'effet de la connexion entre ces systèmes sur le processus de régulation de la prise alimentaire est médié par les histamines H1 et H3 ainsi que par les récepteurs du glutamate NMDA, Kainate et mGluR2 chez les poulets pondeuses néonatales.

Keywords [French]

  • glutamate central
  • Histamine
  • Prise alimentaire
  • poule pondeuse

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Archives of Razi Institute
Volume 76, Issue 3
September 2021
Pages 537-551

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