Comparison of the Immunogenicity of Four Infectious Bursal Disease Intermediate Vaccines in Commercial Broiler Flocks in Iran: A Field Trial Study

Document Type: Original Articles

Authors

1 Department of Poultry Viral Vaccines Research and Production, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran

2 Department of Pathology and Experimental Animals, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran

3 Department of Animal Sciences, College of Agriculture and Natural Resource, University of Tehran, Karaj, Iran

4 Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

Abstract

Infectious bursal disease (IBD) is a highly contagious disease in young chickens worldwide. The major strategy for the prevention and control of IBD virus (IBDV) is vaccination. Therefore, the present study aimed to compare the immunogenicity of four commercially available IBD vaccines on broilers (Ross 308) that were raised in areas with very virulent IBDV infection history. Two commercial broiler farms with four standard poultry houses were selected in Alborz (n=6,250 birds per house) and Khorasan Razavi (n=8,000 birds per house) provinces of Iran. In each farm, the houses were randomly assigned to one of the four IBD intermediate vaccine brands including Dn, Vc, Ch, and Razi. The birds in Alborz were vaccinated against IBDV via drinking water at 18 and 22; and 15 and 21 days of age in Alborz and Khorasan Razavi flocks, respectively. The enzyme-linked immunosorbent assay antibody titers against IBDV were measured in 20 birds per group at 1, 28, 35, and 42 days of age. In addition, production attributes including body weight, feed conversion ratio, mortality, and production index were measured during the research period. According to the findings, the IBD antibody titers were not affected by the vaccine brands at 28, 35, and 42 days of age (P>0.05). Following the second IBD vaccination, an increasing trend in IBD antibody titers was noted in the Razi vaccine as well as other brands at days 35 and 42 compared to the previously recorded titers (P<0.05). Moreover, the production attributes of the flocks receiving various IBDV vaccine brands were not different (P>0.05). Regarding the productivity indices and high immunogenicity levels, the results indicated that the potential of the IBD Razi vaccine was comparable to the other investigated brands of commercial IBD vaccines, and nominated it as an immunogenic candidate vaccine for use in commercial broilers.

Keywords


Article Title [French]

Comparaison de l'Immunogénicité de Quatre Vaccins Intermédiaires contre la Bursite Infectieuse chez les Poulets de Chair Commerciaux en Iran: une Étude de Terrain

Abstract [French]

La bursite infectieuse est une maladie hautement contagieuse chez les jeunes poulets du monde entier. La stratégie principale pour la prévention et le contrôle du virus de la bursite infectieuse est la vaccination. Par conséquent, cette étude visait à comparer l'immunogénicité de quatre vaccins commerciaux contre la bursite infectieuse sur des poulets de chair (Ross 308) élevés dans des zones ayant des antécédents d'infection par le virus très virulent de la bursite infectieuse. Deux fermes commerciales de poulets de chair avec quatre poulaillers standard ont été sélectionnées dans les provinces iraniennes d'Alborz (n = 6,250 oiseaux par poulailler) et de Khorasan Razavi (n = 8,000 oiseaux par poulailler). Dans chaque ferme, les maisons ont été assignées au hasard à l'une des quatre marques de vaccins intermédiaires contre la bursite infectieuse, Dans chaque ferme, les maisons ont été assignées au hasard à l'une des quatre marques de vaccins intermédiaires contre la bursite infectieuse, dont Dn, Vc, Ch et Razi. Les oiseaux d'Alborz ont été vaccinés contre le virus de la bursite infectieuse (IBDV) par l'eau potable à 18 et 22 jours; et à 15 et 21 jours dans les troupeaux d'Alborz et de Khorasan Razavi, respectivement. Les titres d'anticorps obtenus par ELISA contre le virus de la bursite infectieuse ont été mesurés chez 20 oiseaux par groupe aux jours 1, 28, 35 et 42. En outre, les attributs de production, y compris le poids corporel, le taux de conversion alimentaire, la mortalité et l'indice de production ont été mesurés pendant la période de recherche. Selon nos résultats, les titres d'anticorps contre la bursite infectieuse n'ont pas été affectés par les marques de vaccins à 28, 35 et 42 jours (P> 0,05). Après la deuxième vaccination contre la bursite infectieuse, une tendance à la hausse des titres d'anticorps contre la bursite infectieuse a été notée aux jours 35 et 42 par rapport aux titres précédemment enregistrés dans le vaccin Razi ainsi que dans d'autres marques (P <0,05). De plus, les attributs de production des troupeaux recevant diverses marques de vaccins contre le IBDV n'étaient pas différents (P> 0,05). En ce qui concerne les indices de productivité et les niveaux élevés d'immunogénicité, les résultats ont indiqué que le potentiel du vaccin de Razi contre la bursite infectieuse était comparable aux autres marques de vaccins commerciaux contre la bursite infectieuse étudiés, et représente donc un vaccin immunogène candidat à utiliser dans les poulets de chair commerciaux.

Keywords [French]

  • Titre d'anticorps
  • Poulet de chair
  • Immunité
  • Bursite infectieuse
  • Vaccination
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