Effect of Oat (Avena Sativa L.) Extract on Experimental Sciatic Nerve Injury in Rats

Document Type: Original Articles


1 Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran

3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

4 Universal Scientific Education and Research Network, Tabriz, Iran


Peripheral nerve disorders are the most common neurological problems; therefore, it is important to intervene to treat or stop the resulting side effects. This study aimed to investigate the effect of oat extract on experimental sciatic nerve injury in rats. Totally, 50 adult male rats were divided into five groups (n=10). Group 1 was exposed to sham condition, and group 2 was regarded as the control group (nerve injury without treatment). Moreover, groups 3-5 were subjected to sciatic nerve injury, and they received oral gavages of the oat extract (100, 200, and 400 mg/kg), respectively. Subsequently, 2 and 4 weeks later, the rats were euthanized for pathological evaluation of nerve repair. The results showed an increase in the formation of the perineurium and epineurium dose in the oat-treated groups (100, 200, and 400 mg/kg), compared to the control group after 2 weeks (P<0.05). Furthermore, the presence of inflammatory cells in the oat extract-treated groups (100, 200, and 400 mg/kg) decreased, compared to that in the control group after 2 weeks (P<0.05). In addition, the swelling of the axon significantly decreased in the oat extract-treated groups (200 and 400 mg/kg), compared to the control group (P<0.05). However, the axon dose-dependently increased in oat-treated groups (100, 200, and 400 mg/kg), compared to that in the control group after 4 weeks (P<0.05). These results suggest that oat extract has positive effects on sciatic nerve repair in rats.


Article Title [French]

Effet de l'Extrait d'Avoine (Avena Sativa L.) sur des Lésions Expérimentales du Nerf Sciatique chez les Rats

Abstract [French]

Les troubles nerveux périphériques sont parmi les problèmes neurologiques les plus courants. Par conséquent, il est important d'intervenir pour traiter ou arrêter les effets secondaires qui en résultent. Cette étude visait à étudier l'effet de l'extrait d'avoine sur les lésions expérimentales du nerf sciatique chez les rats. Au total, 50 rats mâles adultes ont été divisés en cinq groupes (n = 10). Le groupe 1 a été exposé à des conditions fictives (témoin), et le groupe 2 a été considéré comme le groupe de contrôle (lésion nerveuse sans traitement). Les groupes 3 à 5 ont reçu des gavages oraux d'extrait d'avoine (100, 200 et 400 mg/kg), respectivement. Par la suite, les rats ont été euthanasiés 2 et 4 semaines plus tard, pour l’évaluation pathologique de la réparation nerveuse. Les résultats ont montré une augmentation de la formation des périnèvre et épinèvre dans les groupes traités à l'avoine (100, 200 et 400 mg/kg), par rapport au groupe de contrôle après 2 semaines (P <0,05). En outre, la présence de cellules inflammatoires dans les groupes traités à l'extrait d'avoine (100, 200 et 400 mg / kg) a diminué par rapport à celle du contrôle après 2 semaines (P <0,05).De plus, le gonflement de l'axon a considérablement diminué dans les groupes traités à l'extrait d'avoine (200 et 400 mg / kg), par rapport au groupe de contrôle (P <0,05). Cependant, l'axone a augmenté en fonction de la dose dans les groupes traités par l'avoine (100, 200 et 400 mg / kg), par rapport à celui du groupe de contrôle après 4 semaines (P <0,05). Ces résultats suggèrent que l'extrait d'avoine a des effets positifs sur la réparation du nerf sciatique chez les rats.

Keywords [French]

  • Extrait d'avoine
  • rat
  • Lésion du nerf sciatique
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