Investigation of the Effects of Spinal Dexamethasone Injection as a Premedication in Rabbit Anesthesia

Document Type: Original Articles


1 Department of Clinical Science, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Pathobiology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran


Anesthesia and analgesia are important in human and veterinary medicine, especially in surgical procedures. Rodents, avians, and exotic species are required to be anesthetized using an appropriate anesthetic regimen. This study aimed to suggest a new anesthetic drug and method in order to facilitate anesthesia as well as analgesia among rabbits, laboratory animals, and humans. Spinal injection of dexamethasone combined with intramuscular ketamine among rabbits can play the role of premedication agents. A total of 24 healthy white adult rabbits from New-Zealand were equally assigned into four groups. Groups 1, 2, 3, and 4 were subjected to spinal xylazine (5mg/kg) with ketamine (35mg/kg,IM), spinal dexamethasone (0.37mg/kg-four times diluted) with ketamine (35mg/kg,IM), dexamethasone (4mg/kg,IM) with ketamine (35mg/kg,IM), and spinal dexamethasone (0.37mg/kg-four times diluted), respectively. The results showed that there was a significant difference in terms of clinical reflexes recorded for group 2, compared to groups 1 and 3. A significant difference was also observed regarding clinical reflexes between group 2 and the other groups. Furthermore, no abnormality was observed in terms of histological sections within groups 2 and 4. Spinal dexamethasone can be used as a premedication combined with ketamine in rabbit anesthesia.


Main Subjects

Article Title [French]

Étude des effets de l'injection spinale de dexaméthasone en tant que prémédication lors de l'anesthésie chez le lapin

Abstract [French]

L'anesthésie et l'analgésie sont importantes en médecine humaine et vétérinaire, en particulier dans les procédures chirurgicales. Les rongeurs, les oiseaux et les espèces exotiques doivent être anesthésiés à l'aide d'un traitement anesthésique approprié. Cette étude visait à suggérer un nouveau médicament anesthésique et une nouvelle méthode afin de faciliter l'anesthésie ainsi que l'analgésie chez les lapins, les animaux de laboratoire et les humains. L'injection spinale de dexaméthasone associée à de la kétamine par voie intramusculaire chez le lapin peut ȇtre ulisée comme prémédication. Au total, 24 lapins blancs adultes de Nouvelle-Zélande, en bonne santé, ont été également répartis dans quatre groupes. Les groupes 1, 2, 3 et 4 ont été soumis à une xylazine spinale (5 mg/kg) avec de la kétamine (35mg/kg, IM), de la dexaméthasone spinale (0.37mg/kg diluée quatre fois) accompagnée de kétamine (35mg/kg,IM), dexaméthasone (4mg/kg,IM) et kétamine (35mg/kg,IM) et la dexaméthasone spinale (0.37mg/kg, diluée quatre fois). Les résultats ont montré qu'il existait une différence significative en termes de réflexes cliniques enregistrés pour le groupe 2 par rapport aux groupes 1 et 3. Une différence significative a également été observée concernant les réflexes cliniques entre le groupe 2 et tous les autres groupes. De plus, aucune anomalie n'a été observée au niveau des coupes histologiques dans les groupes 2 et 4. La dexaméthasone spinale peut donc être utilisée comme prémédication en association avec de la kétamine lors d'une anesthésie chez le lapin.

Keywords [French]

  • Anesthésie
  • Dexaméthasone
  • Prémédication
  • Lapin
  • Colonne vertébrale
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