Comparative Evaluation of the Biochemical Effects of Ketamine plus Ketoprofen and Midazolam in the Premedication of Pigeons

Document Type : Original Articles

Authors

1 Department of Veterinary Surgery, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Pathology, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

Abstract

The present study was conducted with the aim of comparing the effects of premedication with ketoprofen and midazolam in birds. A total of 24 male pigeons with an approximate weight of 300 g were divided into four equal groups. The control group (Group I) was injected with ketamine alone. Groups II-IV were injected with ketoprofen alone, ketoprofen+ketamine, and midazolam+ketamine, respectively. The biochemical changes in the four groups were evaluated after intramuscular drug injections at different anesthetic levels. A record of biochemical changes was maintained for each group. Blood samples were taken before and after the administration of the medications in order to measure the levels of serum alkaline phosphatase (ALP), oxaloacetate transaminase (OT), prothrombin time (PT), glucose (GLU), lactate dehydrogenase (LDH), albumin (Alb), total protein (TP), and gamma-glutamyl transferase (GGTF). The results showed significant differences in the mean levels of ALP, OT, PT, GLU, LDH, Alb, and TP after anesthesia, compared to that before anesthesia. Therefore, ketoprofen+ketamine can be used for the induction of anesthesia in birds.The present study was conducted with the aim of comparing the effects of premedication with ketoprofen and midazolam in birds. A total of 24 male pigeons with an approximate weight of 300 g were divided into four equal groups. The control group (Group I) was injected with ketamine alone. Groups II-IV were injected with ketoprofen alone, ketoprofen+ketamine, and midazolam+ketamine, respectively. The biochemical changes in the four groups were evaluated after intramuscular drug injections at different anesthetic levels. A record of biochemical changes was maintained for each group. Blood samples were taken before and after the administration of the medications in order to measure the levels of serum alkaline phosphatase (ALP), oxaloacetate transaminase (OT), prothrombin time (PT), glucose (GLU), lactate dehydrogenase (LDH), albumin (Alb), total protein (TP), and gamma-glutamyl transferase (GGTF). The results showed significant differences in the mean levels of ALP, OT, PT, GLU, LDH, Alb, and TP after anesthesia, compared to that before anesthesia. Therefore, ketoprofen+ketamine can be used for the induction of anesthesia in birds.

Keywords

Article Title [French]

Évaluation Comparative des Effets de la Kétamine, Combinée au Kétoprofène et au Midazolam dans la Prémédication des Pigeons

Abstract [French]

Cette étude a été menée fin but de comparer les effets de la prémédication avec le kétoprofène et le midazolam chez les oiseaux. Au total, 24 pigeons mâles d'un poids approximatif de 300 g ont été répartis en quatre groupes égaux. Le groupe témoin (Groupe I) a été injecté avec de la kétamine seule. Les groupes II-IV ont reçu respectivement une injection de kétoprofène seul, de kétoprofène combiné à la kétamine et de midazolam combiné à la kétamine. Les modifications biochimiques dans les quatre groupes ont été évaluées après des injections intramusculaires à différents niveaux d’anesthésie. Les modifications observées ont été ensuite enregistrées pour chaque groupe. Des échantillons de sang ont été prélevés avant et après l'administration des médicaments afin de mesurer les taux de phosphatase alcaline sérique (PAL), oxaloacétate transaminase (OT), taux de prothrombine (TP), glucose (GLU), lactate déshydrogénase (LDH), albumine (Alb), protéine totale (PT) et gamma-glutamyltranspeptidase (γ-GT). Les résultats ont montré des différences significatives dans les niveaux moyens de PAL, d'OT, de TP, de GLU, de LDH, d'Alb et de PT après anesthésie, comparés à ceux avant l'anesthésie. Par conséquent, le kétoprofène combiné à la kétamine peut être utilisé pour l'induction de l'anesthésie chez les oiseaux.

Keywords [French]

  • Analyse du Sérum
  • Kétamine
  • Kétoprofène
  • Midazolam
  • Pigeons

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Archives of Razi Institute
Volume 73, Issue 3
September 2018
Pages 223-227

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