Razi Vaccine & Serum Research Institute Co-Publisher: Negah Scientific Publisher Archives of Razi Institute 0365-3439 71 4 2016 12 01 The effect of equine chorionic gonadotrophin (ecg) injection combined with prostaglandin F2α (pGF2α) and gonadotrophin releasing hormone (GnRH) treatment on reproductive performance of Zandi ewes during non-breeding season اثر تزریق eCG به همراه PGF2α و GnRH بر عملکرد تولیدمثلی میش های زندی در خارج فصل تولیدمثل 269 279 107512 10.22034/ari.2016.107512 EN A. Hosseinzadeh Aski Department of Animal Science, Faculty of Veterinary, Islamic Azad University, Ghaemshahr Branch, Ghaemshahr, Iran R. Masoudi Department of Animal Science, Faculty of Agriculture and Natural Resources, University of Tehran, Karaj, Iran A. Zare Shahneh Department of Animal Science, Faculty of Agriculture and Natural Resources, University of Tehran, Karaj, Iran S. Asadzadeh Department of Animal Science, Faculty of Veterinary, Islamic Azad University, Ghaemshahr Branch, Ghaemshahr, Iran E. Dirandeh Department of Animal Science, Faculty of Agriculture, Sari University of Agricultural Sciences and Natural Resources, Sari, Iran H. Sadeghipanah Animal Science Research Institute, Karaj, Iran Journal Article 2016 12 24 In this study, we aimed to investigate reproductive performance in estrus-induced Zandi ewes treated with equine chorionic gonadotrophin (eCG) injection in combination with prostaglandin F₂α (PGF₂α)and gonadotrophin releasing hormone (GnRH) during non-breeding season. The estrous cycle was synchronized using controlled internal drug release (CIDR) for 12 days. The ewes were randomly assigned to five groups (n=100 in each group). The first group (control) did not receive hormone injection, the second group (eCG) received 400 IU of eCG at the time of CIDR removal, the third group (eCG+PGF2α) received 400 IU of eCG and 1 ml of PGF2α at the time of CIDR removal, the fourth group (eCG+GnRH) received 400 IU of eCG at the time of CIDR removal and 1 ml of GnRH injection on the day of insemination, and the fifth group (eCG+PGF2α+GnRH) received 400 IU of eCG, 1 ml of PGF2α at the time of CIDR removal, and 1 ml of GnRH on the day of insemination. The results showed that the heat response rate was higher in all the groups receiving hormonal injections compared with the control group (P<0.05). In addition, the lambing and parturition rateswere significantly (P<0.05) higher in the groups receiving GnRH compared with other treatments.In fact, in groups receiving eCG and PGF2α, lambing and parturition rateswere higher than the control group (P>0.05). In conclusion, use of eCG at the time of CIDR removal and GnRH on the day of insemination increased reproductive performance. Therefore, it can be applied as a strategy for increasing lambing rate in ewes. https://archrazi.areeo.ac.ir/article_107512_ae58f731b8ff494b52b72efedddaa79f.pdf