TY - JOUR ID - 124876 TI - Analytical Computation of Interleukin17A Activity in Breast Cancer Patients Using Bioinformatics Methods JO - Archives of Razi Institute JA - ARI LA - en SN - 0365-3439 AU - Mohammed, A. S AU - Al-Janabi, A. A AD - Department of Applied Sciences, University of Technology, Baghdad, Iraq Y1 - 2021 PY - 2021 VL - 76 IS - 4 SP - 895 EP - 901 KW - Bioinformatics KW - Breast cancer KW - IL-17A DO - 10.22092/ari.2021.355942.1743 N2 - Interleukin-17A (IL-17A) is a member of the Interleukin-17 family, which belongs to the pro-inflammatory cystine-knot cytokines. Recent studies on the etiology of breast cancer have focused on the role of immunity and inflammation. The pro-inflammatory cytokines IL-17A can medicate cancer-related inflammation. The present study aimed to analyze the mutation in physicochemical properties and structure of the Interleukin-17Agenein developing breast cancer using bioinformatics methods. A total of 60 blood samples were obtained from Iraqi women aged 25 to 75 with breast cancer. Twenty blood samples were obtained from healthy women in the same age range as a control group. Deletion and missense mutations detected by BLAST in samples with breast cancer. The present study determined the physicochemical properties of IL-17A such as hydrophilic nature, alpha-helical and 3D structure. The results of this study indicated that IL-17Ais considered a marker for a patient with breast cancer. Also, mutations in the IL-17Agene affect the structure and physicochemical properties of the IL-17A protein complex. UR - https://archrazi.areeo.ac.ir/article_124876.html L1 - https://archrazi.areeo.ac.ir/article_124876_fed4cc69b601c9d559bcbf3f063d026a.pdf ER -