TY - JOUR ID - 121555 TI - Detection and Phylogenetic Study of Peste des Petits Ruminants in Iran, 2019: Updated Data JO - Archives of Razi Institute JA - ARI LA - en SN - 0365-3439 AU - Alidadi, N AU - Aghaeean, L AU - ZiafatiKafi, Z AU - Hamedi, M AU - Fallah Mehrabadi, M. H AU - Ghalyanchilangeroudi, A AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran AD - Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran AD - Iranian Veterinary Organization, Tehran, Iran AD - Department of Poultry Diseases, RAZI Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran Y1 - 2021 PY - 2021 VL - 76 IS - 1 SP - 161 EP - 166 KW - Goat KW - Iran KW - Lineage KW - Peste des Petits Ruminants KW - phylogenetic KW - RT-PCR DO - 10.22092/ari.2019.126677.1351 N2 - Peste des Petits Ruminants (PPR) is caused by a morbillivirus from the Paramyxoviridae family and the infected animals, especially goats, that show clinical signs of necrotic stomatitis, enteritis, and pneumonia. The PPR virus has four lineages closely related to the geographical regions. Sufficient awareness of the lineage of the virus helps monitor the disease in different regions of a country. Phylogenetic studies have led to implementing strategies against new lineages that may enter a given country from the neighboring countries. The present research aimed to study the PPR virus (PPRV) detected phylogenetically by PCR in a small ruminant flock with PPR clinical signs. The goats in a flock in Alborz province showed clinical signs of PPR, and 10% died. Oral swabs and blood samples were taken from two affected goat flocks. The RT-PCR was conducted to detect PPRV RNA, and the sequence of the obtained RNA was analyzed phylogenetically. Moreover, all the samples were positive for the presence of PPRV and belonged to lineage IV. The isolates had high homology with each other and with the isolates from different countries. To inhibit the entrance of new isolates to Iran and reduce the incidence of outbreaks in Iran, it is essential to control the animals’ movement across the borders and increase the vaccination coverage throughout the country. To eradicate PPR, an extensive vaccination program should cover small ruminant populations throughout the country. UR - https://archrazi.areeo.ac.ir/article_121555.html L1 - https://archrazi.areeo.ac.ir/article_121555_1c752f2a337109c4210233f0a14b4b47.pdf ER -