@article { author = {Abedini, F. and Moharrami, M. and Shams, P. and Eslampanah, M. and Adeldost, H. and Ebrahimi, M. and Vaziri, A. and Talebloo, F.}, title = {Detection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological Studies}, journal = {Archives of Razi Institute}, volume = {69}, number = {1}, pages = {83-88}, year = {2014}, publisher = {Razi Vaccine & Serum Research Institute}, issn = {0365-3439}, eissn = {2008-9872}, doi = {10.7508/ari.2014.01.012}, abstract = {Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered from laboratory animals department. Histopathology and polymerase chain reaction (PCR) tests were done on breast tissue samples. Formalin-fixed tissue specimens were obtained from mouse normal breast tissues (n:17) and mouse mammary tumors (n:17). Detection of mouse cytomegalovirus was done by the pUC57-MCK-2 plasmid. Our histopathology data showed Adenocarcinoma type B in mouse with mammary tumors. There was a significant difference between mice with spontaneous breast cancer and control by Pearson Chi-Square (Value: 17.000b and P=0.000). More research will be needed to determine the effect of cytomegalovirus on breast cancer.}, keywords = {Mouse Cytomegalovirus,Breast cancer,Human cytomegalovirus,MCK,2 Gene}, url = {https://archrazi.areeo.ac.ir/article_103939.html}, eprint = {https://archrazi.areeo.ac.ir/article_103939_709288b834963674ed9ec30bdc395ac7.pdf} }