@article { author = {Tabatabayi, M. and Mosallanejad, B. and Mohebali, M. and Malmasi, A. and Bahonar, A. and Sasani, F.}, title = {Inhibitory effects of Clindamycin on shedding of Toxoplasma gondii oocyst and its comparison with Monensin in kitten}, journal = {Archives of Razi Institute}, volume = {61}, number = {1}, pages = {41-47}, year = {2006}, publisher = {Razi Vaccine & Serum Research Institute}, issn = {0365-3439}, eissn = {2008-9872}, doi = {10.22092/ari.2006.103725}, abstract = {  The efficacy of Clindamycin and Monensin were evaluated in the prevention of oocyst shedding of kittens with Toxoplasma gondii (Tehran strain). In this study, 28 healthy kittens aged 1.5 – 2 months old divided randomly into 4 groups of seven. In group 1, Kittens were fed with the infected brain tissues of mice, all of seven kittens (100 %), shed oocyst, nearly 1 week after infection, which lasted for 8 to 9 days. In group 2, kittens were fed with infected brain tissues of mice and Clindamycin at dose of 20 mg/kg from day -3 to + 21 after infections, none of seven kittens, shed any oocyst. In group 3, kittens were fed with Clindamycin at dose of 10 mg/kg, same as group 2, two of 7 kittens (28/6%), began to shed oocyst from day 11 to 18 after infection. Kittens of group 4 that were fed with Monensin at dose of 0.02 % incorporated in dry food did not shed any oocyst. Data analysis revealed that Clindamycin 20mg/kg and Monensin 0.02% had a 100% inhibitory effect against Toxoplasma gondii (Tehran strain). No adverse reactions were observed during the experimental period.  }, keywords = {Clindamycin,monensin,Toxoplasma gondii,Oocyst shedding,kitten,Tehran strain}, url = {https://archrazi.areeo.ac.ir/article_103725.html}, eprint = {https://archrazi.areeo.ac.ir/article_103725_25ff0b95e6b8acd2a60f970f6a6ced5d.pdf} }