Document Type : Original Articles
Authors
1
College of nursing, University of Human Development, Sulaimani, KRG, Iraq
2
College of Health science, University of Human Development, Sulaimani, KGR, Iraq
3
Nursing Department, Darbandikhan Technical Institute, Sulaimani Polytechnic University, Sulaimani, KGR, Iraq
4
department of biology, college of science, University of Sulaimani, Sulaimani, KRG, Iraq
5
Department of animal science, college of agriculture engineering science, University of Sulaimani, Sulaimani, KRG, Iraq
6
Department of nursing, college of health and medical technology, Sulaimani Polytechnic University, Sulaimani, KGR, Iraq
10.22092/ari.2024.364596.2994
Abstract
Abstract
Background: Hyperuricemia is considered the main cause of many chronic and metabolic diseases. Hyperuricemia causes hyperlipidemia, increased serum creatinine, hyperglycemia, and weight gain through different pathways and mechanisms. The aim of this study was to investigate the effect of Beta vulgaris and Laurus nobilis on reducing the risk of hyperuricemia in developing metabolic disorders and kidney damage in a rat model. Methods: Twenty-four adult male albino rats of about 200–220 g body weight and 8–12 weeks old were kept in the animal house. The hyperuricemia rats, model group were given oxonic acid (250 mg/kg/bw). Treatment groups were administered either Beta vulgaris or Laurus nobilis after induced hyperuricemia. Histopathological examination of kidney tissue and biochemical tests were done for all groups of rats. Results: Except for HDL, all biochemical parameters, including cholesterol (49.00±6.48), triglyceride (47.25±2.22), LDL (34.50±3.11), uric acid (4.90±0.22), urea (46.00±0.82), creatinine (0.35±0.03), blood sugar (193.00±11.20), and weight gain (77.75±2.06), were significantly decreased in the rats administered Laurus nobilis and Beta vulgaris treatments compared to hyperuricemia model rat (P. value ≤0.01). Nephron structure in Beta vulgaris and Laurus nobilis rat was less damaged. Conclusion: This study found hyperuricemia induces kidney damage and several metabolic disorders such as dyslipidemia, hyperglycemia, increased serum creatinine and urea, and weight gain in model rats. Beta vulgaris and Laurus nobilis decrease the biochemical parameters, and ameliorate the histopathological effects of hyperuricemia, such as atrophy of glomeruli and hydropic changes in the epithelial lining of proximal convoluted tubules. Laurus nobilis physiologically has a greater effect on lipid profile, blood glucose, serum creatinine, weight, and urea compared to Beta vulgaris.
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