Vitamin D or calciferol, is a fat soluble vitamin that has a unique feature as it considered as the only vitamin that synthesizing in the body, primarily by exposition to UV-light from the sun and then is transformed to 25(OH)D by lever and finally to a vital form 1,25-dihydroxy D by the kidney. Gene polymorphism of vitamin D receptor (FokI-rs2228570) gene has been proposed as the major cause of anemia. The goal of this research was to discover the link between vitamin D insufficiency and the gene polymorphism for vitamin D receptor (FokI-rs2228570) in anemic patients. A case-control study including 120 men anemic patients without any kidney disorders have been compared with 60 healthy men as a control. One single nucleotide polymorphism (SNP) FokI-rs2228570 was detected by "PCR and PCR-RFLP" techniques. Serum vitamin D, erythropoietin levels and some biochemical parameters were detected by ELISA. The mutant homozygous genotype ff were more frequent in anemic patients (45%) than control (15%), also the f allele frequency were the common allele in patients group (0.62%) with significant decrement of vitamin D and hemoglobin levels, this mean that the presence of mutant allele represent the risk factor for developing anemia compared with genetic patterns FF and Ff. Vitamin D insufficiency is It's common in anemic people, and it's often accompanied by low hemoglobin and high erythropoietin levels. Additionally, the genetic frequencies also affect vitamin D conditions as indicated by low levels in mutant patterns (Ff, ff) in which the patients suffer from severe anemia.
H. Mohamed, A., S. AlKhafaji, R., & H. Al-Saadi, A. (2024). Correlation between vitamin D deficiency and vitamin D receptor (FokI-rs2228570) gene polymorphisms of Anemic Men in Babylon Province. Archives of Razi Institute, (), -. doi: 10.22092/ari.2022.357805.2102
MLA
Asma'a H. Mohamed; Rafie S. AlKhafaji; Ali H. Al-Saadi. "Correlation between vitamin D deficiency and vitamin D receptor (FokI-rs2228570) gene polymorphisms of Anemic Men in Babylon Province". Archives of Razi Institute, , , 2024, -. doi: 10.22092/ari.2022.357805.2102
HARVARD
H. Mohamed, A., S. AlKhafaji, R., H. Al-Saadi, A. (2024). 'Correlation between vitamin D deficiency and vitamin D receptor (FokI-rs2228570) gene polymorphisms of Anemic Men in Babylon Province', Archives of Razi Institute, (), pp. -. doi: 10.22092/ari.2022.357805.2102
VANCOUVER
H. Mohamed, A., S. AlKhafaji, R., H. Al-Saadi, A. Correlation between vitamin D deficiency and vitamin D receptor (FokI-rs2228570) gene polymorphisms of Anemic Men in Babylon Province. Archives of Razi Institute, 2024; (): -. doi: 10.22092/ari.2022.357805.2102
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