Impact of Phytobacterial Agent on the Toxic Damage to the Liver and Ileum of White Rats

Document Type: Original Articles

Authors

1 Testing Laboratory Center, Buryat State Agricultural Academy named after V. R. Filippov, Ulan-Ude, Russia

2 Department of Ecology, Subsoil Use and Life Safety, East Siberia State University of Technologiy and Management, Ulan-Ude, Russia

3 LLC Small Innovative Enterprise "Bifimed", Ulan-Ude, Russia

Abstract

Numerous pharmaceutical agents can induce adverse reactions in the human body, including toxicity to the liver and the inflammation of intestines. Therefore, nowadays one of the most urgent problems in modern medical science is the prevention and restoration of morphological and dysbiosis disorders caused by numerous medications. With this background in mind, we aimed to evaluate the efficacy of phytobacteria on toxic damage to the structure and function of the liver and ileum, as well as the composition of the large intestine microflora in white rats with intestinal dysbacteriosis due to carbon tetrachloride (CCl4) and ampicillin trihydrate. In order to prevent toxic damage to the liver and ileum of experimental animals, a phytobacterial agent was used. This test agent was composed of a mixture of commercial lactobacteria Lactobacillus helveticus with a water-soluble extract of thyme (Thymus Serpyllum L.) on a sterile milk basis. Our results showed that the introduction of phytobacterial agent led to reduced inflammation, accelerated regeneration of the ileum mucous membrane, and a positive effect on the damaged intestine. The phytobacterial agent increased the resistance of the body to potentially pathogenic microorganisms and toxic compounds by restoring the microflora of the large intestine. It was established that the phytobacterial remedy resulted in the normalization of the intestinal microflora of white rats, which had toxic damage to the liver and ileum caused by CCl4 and ampicillin trihydrate administration. Moreover, the usage of phytobacteria was correlated with improvement in the structure and function of the liver and ileum.

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Main Subjects


Article Title [French]

Impact de L'agent Phytobactérien sur les Dommages Toxiques au Foie et à L'iléon des Rats Blancs

Abstract [French]

De nombreux agents pharmaceutiques peuvent induire des réactions indésirables dans le corps humain, notamment une toxicité hépatique et une inflammation de l'intestin. Par conséquent, l'un des problèmes les plus urgents de la science médicale moderne est la prévention et la restauration des troubles morphologiques et de la dysbiose provoqués par de nombreux médicaments. Dans cet esprit, nous souhaitions évaluer l’efficacité des phytobactéries sur les dommages toxiques causés à la structure et au fonctionnement du foie et de l’iléon, ainsi que la composition de la microflore du gros intestin chez des rats blancs atteints de dysbactériose intestinale due au tétrachlorure de carbone (CCl4) et trihydrate d’ampicilline. Afin de prévenir les dommages toxiques au foie et à l'iléon d'animaux expérimentaux, un agent phytobactérien a été utilisé. Cet agent d'essai était composé d'un mélange de lactobactéries commerciales Lactobacillus helveticus et d'un extrait hydrosoluble de thym (Thymus Serpyllum L.) à base de lait stérile. Nos résultats ont montré que l'introduction d'un agent phytobactérien entraînait une réduction de l'inflammation, une régénération accélérée de la membrane muqueuse de l'iléon et un effet positif sur l'intestin endommagé. L'agent phytobactérien a augmenté la résistance des rats aux micro-organismes potentiellement pathogènes et aux composés toxiques en restaurant la microflore du gros intestin. Il a été établi que le traitement phytobactérien entraînait la normalisation de la microflore intestinale de rats blancs, qui présentait des lésions toxiques du foie et de l’iléon causées par l’administration de CC14 et de trihydrate d’ampicilline. De plus, l'utilisation de phytobactéries était corrélée à une amélioration de la structure et de la fonction du foie et de l'iléon.

Keywords [French]

  • Dysbiose
  • Iléon
  • Foie
  • Phytobacterium
  • Probiotiques
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