Novel Applications of Immuno-bioinformatics in Vaccine and Bio-product Developments at Research Institutes

Document Type: Review Article

Authors

1 Department of FMD, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

2 Department of Avian Vaccine,Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

3 Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Department of Genetics, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

5 Department of Serotherapy, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

Abstract

There are many challenges in the field of public health sciences. Rational decisions are required in order to treat different diseases, gain knowledge and wealth regarding research, and produce biological or synthetic products. Various advances in the basic laboratory science, computer science, and the engineering of biological production processes can help solve the occurring problems. Bioinformatics is defined as a field of science combined of biology, mathematics, physics, chemistry, and computer sciences. Recently, bioinformatics has been extensively used in the designing of the epitope, vaccines, antibodies, adjuvants, diagnostic kits, and therapeutic purposes (e.g., proteins, peptides, or small molecules). Moreover, bioinformatics includes chemoinformatics that has been employed to produce various biological or chemical products to target and combat pathogens. Bioinformatics is involved in other areas of data analysis and prediction, such as structural biology, system biology, phylogeny, population genetics, and next-generation data sequencing. To the best of our knowledge, no published study coherently described the benefits of bioinformatics fields applied for medication development or diagnostic aims in bio-productive and pharmaceutical/vaccine companies. Therefore, in the current review, we attempted to present the available bioinformatics resources, practical experiences, and other findings in the mentioned field along with providing a harmonized and applied model(s). The key points presented in the current review may help to elevate production and reduce the costs for the development of novel vaccines, medicines, and antibodies. In addition, these methods can facilitate the identification of organisms and may guarantee the quality of biological products.

Keywords

Main Subjects


Article Title [French]

Nouvelles applications de l’immuno-bioinformatique dans le développement de vaccins et de bioproduits dans les instituts de recherche

Abstract [French]

Il existe de nombreux défis dans le domaine des sciences de la santé publique. Des décisions rationnelles sont nécessaires pour traiter différentes maladies, acquérir des connaissances et une richesse en matière de recherche et produire des produits biologiques ou synthétiques. Divers progrès dans les sciences fondamentales de laboratoire, l'informatique et l'ingénierie des processus de production biologique peuvent aider à résoudre les problèmes qui se posent. La bioinformatique est définie comme un domaine scientifique d'objectifs thérapeutiques (protéines, peptides ou petites molécules, par exemple). De plus, la bioinformatique comprend la chimioinformatique qui a été utilisée pour produire divers produits biologiques ou chimiquescombinant biologie, mathématiques, physique, chimie et informatique. Récemment, la bioinformatique a été largement utilisée dans la conception d'épitopes, de vaccins, d'anticorps, d'adjuvants, de kits de diagnostic et destinés à cibler et à combattre les agents pathogènes. La bioinformatique intervient dans d'autres domaines de l'analyse et de la prévision des données, tels que la biologie structurale, la biologie des systèmes, la phylogénie, la génétique des populations et le séquençage de la prochaine génération (NGS). Au meilleur de nos connaissances, aucune étude publiée ne décrivait de manière cohérente les avantages des domaines de la bioinformatique appliqués au développement de médicaments ou d’outils de diagnostic dans les entreprises de bioproduction de vaccins et dans les sociétés pharmaceutiques. Par conséquent, dans cette revue de la litérature, nous avons tenté de présenter les ressources en bioinformatique disponibles, les expériences pratiques et d’autres résultats dans le domaine mentionné, tout en fournissant un ou plusieurs modèles harmonisés et appliqués. Les points clés présentés dans le présent rapport pourraient contribuer à augmenter la production et à réduire les coûts de développement de nouveaux vaccins, médicaments et anticorps. De plus, ces méthodes peuvent faciliter l'identification des organismes et garantir la qualité des produits biologiques.

Keywords [French]

  • Bioinformatique
  • Produits biologiques
  • Immuno-informatique
  • Vaccin
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