Polyomavirus-Associated Progressive Multifocal Leukoencephalopathy (PML) in HAART era

Document Type: Review Article


Department of Human Viral Vaccine, Razi Vaccine and Serum Research Institute, Karaj, Iran


Polyomaviruses may cause human disease, particularly in immunocompromised hosts. JCV, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (PML), which occurs mostly in immunocompromised patients. Progressive Multifocal leukoencephalopathy (PML) is a progressive demyelinating disorder of the central nervous system (CNS) resulting from infection of oligodendrocytes by JC polyomavirus. Whereas after highly active antiretroviral therapy (HAART), the incidence of nearly all of all neurological complication have decreased, this article evaluates the incidence and prognosis of JC polyomavirus-associated PML including a unchangeable incidence of PML associated with JC polyomavirus compared with other opportunistic disease and paradoxical results of disease remission in HAART era.


Main Subjects

Article Title [French]

La leucoencéphalopathie multifocale progressive (LEMP) associée au Polyomavirus à l’ère de l’HAART

Abstract [French]

Le polyomavirus peut affecter l’homme, particulièrement les individus immunodéprimés. Le JVC, l’un des membres de la famille des Polyomaviridae, est l’agent responsable d’une maladie neurologique, la leucoencéphalopathie multifocale progressive (LEMP). La LEMP est une maladie démyélinisante progressive du système nerveux central résultant de l’infection des oligodendrocytes par le polyomavirus JC. Il est avéré qu’après une thérapie antirétrovirale fortement active (HAART), l’incidence des complications neurologiques associées à cette infection diminue. Cette étude a pour objectif d’évaluer l’incidence et le pronostic médical de la LEMP causée par le polyomavirus JC en comparaison avec les résultats paradoxaux liés à la rémission d’autres maladies opportunistes suite à des traitements HAART.

Keywords [French]

  • Polyomavirus
  • JCV
  • LEMP
  • Epidemiologie

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