TY - JOUR ID - 116402 TI - Chitosan-based Nanoparticles in Mucosal Vaccine Delivery JO - Archives of Razi Institute JA - ARI LA - en SN - 0365-3439 AU - Mehrabi, M. AU - Montazeri, H. AU - Mohamadpour Dounighi, N. AU - Rashti, A. AU - Vakili-Ghartavol, R. AD - Department of Medical Nanotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran AD - Department of Medical Nanotechnology, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Department of Human Vaccine and Serum, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran Y1 - 2018 PY - 2018 VL - 73 IS - 3 SP - 165 EP - 176 KW - Adjuvant KW - Chitosan Nanoparticle KW - Mucosal Vaccine Delivery DO - 10.22092/ari.2017.109235.1101 N2 - Most infectious diseases are caused by pathogenic infiltrations from the mucosal tract. Nowadays, the use of vaccines has been widely investigated for the prevention of different infectious diseases, infertility, immune disorders, malignancies, and allergies. Broad-spectrum adjuvant substances have been studied for immune system stimulation with a greater efficiency against specific antigens. Various adjuvants have been developed such as inorganic, oil-based, and emulsion adjuvants, bacterial products and their derivatives, cytokines, cytosine-guanine dinucleotide (CpG) motifs, and particulate systems. Mucosal vaccine delivery is an alternative route to induce both humoral and cellular immune responses. Applying nanoparticles in vaccine formulations allows not only improved antigen stability and immunogenicity, but also targeted delivery, and consequently, more specific release of the agent of interest. Chitosan nanoparticles have immunological activity and mucoadhesive properties. They have been used as a mucosal vaccine delivery system for many antigens. This review provides an overview of the recent advances in chitosan nanoparticles as a novel mucosal vaccine delivery system. UR - https://archrazi.areeo.ac.ir/article_116402.html L1 - https://archrazi.areeo.ac.ir/article_116402_baf9653b7819cb696ad053fbcca00a5b.pdf ER -