%0 Journal Article %T Detection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological Studies %J Archives of Razi Institute %I Razi Vaccine & Serum Research Institute %Z 0365-3439 %A Abedini, F. %A Moharrami, M. %A Shams, P. %A Eslampanah, M. %A Adeldost, H. %A Ebrahimi, M. %A Vaziri, A. %A Talebloo, F. %D 2014 %\ 05/01/2014 %V 69 %N 1 %P 83-88 %! Detection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological Studies %K Mouse Cytomegalovirus %K Breast cancer %K Human cytomegalovirus %K MCK %K 2 Gene %R 10.7508/ari.2014.01.012 %X Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered from laboratory animals department. Histopathology and polymerase chain reaction (PCR) tests were done on breast tissue samples. Formalin-fixed tissue specimens were obtained from mouse normal breast tissues (n:17) and mouse mammary tumors (n:17). Detection of mouse cytomegalovirus was done by the pUC57-MCK-2 plasmid. Our histopathology data showed Adenocarcinoma type B in mouse with mammary tumors. There was a significant difference between mice with spontaneous breast cancer and control by Pearson Chi-Square (Value: 17.000b and P=0.000). More research will be needed to determine the effect of cytomegalovirus on breast cancer. %U https://archrazi.areeo.ac.ir/article_103939_709288b834963674ed9ec30bdc395ac7.pdf